DESCRIPTION ADDITIONAL INFORMATION REVIEW PRODUCT ENQUIRY
Diazepam is indicated for the management of anodiety disorders or for the shortterm relief of the symptoms of anociety. Anociety or tension associated with the stress of everyday life usually does not require treatment with an anciolytic. In acute alcohol withdrawal, Diazepam may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis. Diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology such as inflammation of the muscles or joints, or secondary to trauma), spasticity caused by upper motor neuron disorders (such as cerebral palsy and paraplegia), athetasis, and stiff-man syndrome.
Oral Diazepam may be used adjunctively in convulsive disorders, although it has not proved useful as the sole therapy
The effectiveness of Diazepam in long-term use, that is more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
Benzodiazepine sedatives, Centrally acting Skeletal Muscle Relaxants, Primary anti-epileptic drugs Pharmacology IV Infusion IV Injection IVIM Injection Lotion Naal Drop Nasal Spray Ointment Ophthalmic Suspension Oral Solution Oral Suspension Other’s Paediatric Drops Per-filled Dowder Powder For Suspension Shampoo Scap Solution Sera Suppository Suspension Syrup Tablet Diazepam, like other members of the benzodiazepine family, binds to receptors in various regions of the brain, such as the spinal cord, brain stem, cerebe um limbic system and cerebral cortex Binding of diazepam to the benzodiazepine receptor potentiates the inhibitory actions of gamma-aminobutyric acid (GABA) mediated through chloride channel, thereby enhancing GABA-facilitated, inhibitory synaptic transmission Dosage & Administration Dosage should be individualized for maximum beneficial effect. While the usual daily dosages given below will meet the needs of most patients, there we be some who may require higher doses. In such cases dosage should be increased cautiously to avoid adverse effects.
Management of Anxiety Disorders and Relief of Symptoms of Anciety. Depending upon severity of symptoms 2 mg to 10 mg 2 to 4 times daily
Symptomatic Relief in Acute Alcohol Withdrawal: 10 mg 3 or 4 times during the first 24 hours, reducing to 5 m 3 or 4 times daily as needed
Adjunctively for Relief of Skeletal Muscle Spasm: 2 mg to 10 mg 3 or 4 times daily
Adjunctively in Convulsive Disorders: 2 mg to 10 mg 2 to 4 times daily
Geriatric Patients, or in the presence of debilitating disease: 2 mg to 25 mg, 1 or 2 times daily initially, increase gradually as needed and tolerated
Because of varied responses to CNS-acting drugs, initiate therapy with lowest dose and increase as required. Not for use in pediatric patients under 6 months: 1 mg to 2.5 mg 3 or 4 times daily initially, increase gradually as needed and tolerated
Diazepam may potentiate or interact with the effects of other CNS acting drugs such as alcohol, narcotics, hypnotics, sedative antihistamines, antipsychotics, anxiolytics/ sedatives, anesthetics, antidepressants and anticonvulsants. Besides these diazepam may interact with phenytoin, cimetidine, levodopa, lithium. Contraindications:
Patients with known hypersensitivity to benzod azepines, & myasthenia gravis are contraindicated to
Drowsiness and lightheadedness the next day, confusion and ataxia (specially in the elderly camnesia may occur;dependence, paradoxical increase in aggression; occasionally headache, vertigo, hypotension, gastrointestinal disturbances, visual disturbances, dysarthria, tremor, changes in libido, incontinence, urinary retention, blood disorders and jaundice reported.